Limited Sampling Strategy for Estimation of Amikacin Optimal Sampling Time in Critically Ill Adults
نویسندگان
چکیده
منابع مشابه
Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients.
Because the sepsis-induced pharmacokinetic (PK) modifications need to be considered in aminoglycoside dosing, the present study aimed to develop a population PK model for amikacin (AMK) in severe sepsis and to subsequently propose an optimal sampling strategy suitable for Bayesian estimation of the drug PK parameters. Concentration-time profiles for AMK were obtained from 88 critically ill sept...
متن کاملLimited-sampling strategies for anidulafungin in critically ill patients.
Efficacy of anidulafungin is driven by the area under the concentration-time curve (AUC)/MIC ratio. Determination of the anidulafungin AUC along with MIC values can therefore be useful. Since obtaining a full concentration-time curve to determine an AUC is not always feasible or appropriate, limited-sampling strategies may be useful in adequately estimating exposure. The objective of this study...
متن کاملOptimal sampling and limited sampling strategies for estimation of unbound platinum AUC after nedaplatin infusion.
The aim of this study was to determine the optimal sampling design for empirical Bayesian forecasting for nedaplatin, and also to develop a simple formula for estimating the area under the plasma concentration-time curve (AUC) of platinum which relates to hematological toxicity after nedaplatin dosing using limited sampling points. Plasma unbound platinum concentration data were retrospectively...
متن کاملOptimal Sampling for Parameters Estimation
In the problems concerning prediction and modeling, parameters estimation constitutes one of the main uncertain items that must be taken into account. The easiest way to minimize this uncertainty is to collect great amounts of data. The aim of this work is to build a decision model able to choose the optimal position of the sample point used for the parameters estimation, minimizing the paramet...
متن کاملDetermination of Optimal Sampling Design for Spatial Data Analysis
Extended Abstract. Inferences for spatial data are affected substantially by the spatial configuration of the network of sites where measurements are taken. Consider the following standard data-model framework for spatial data. Suppose a continuous, spatially-varying quantity, Z, is to be observed at a predetermined number, n, of points ....[ To Countinue Click here]
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Anaesthesia and Intensive Care
سال: 2014
ISSN: 0310-057X,1448-0271
DOI: 10.1177/0310057x1404200210